Engineered microbes are of great potential utility in biotechnology and basic research. In principle, a cell can be built from scratch by assembling small molecule sets with auto‐catalytic properties. Alternatively, DNA can be isolated or directly synthesized and molded into a synthetic genome using existing genomic blueprints and molecular biology tools. Activating such a synthetic genome will yield a synthetic cell. Here we examine obstacles associated with this latter approach using a model system whereby a donor genome from H. influenzae (...) is fragmented, and the pieces are then modified and reassembled stepwise in an E. coli host cell. There are obstacles associated with this strategy related to DNA transfer, DNA replication, cross‐talk in gene regulation and compatibility of gene products between donor and host. Encouragingly, analysis of gene expression indicates widespread transcription of H. influenzae genes in E. coli, and analysis of gap locations in H. influenzae and other microbial genome assemblies reveals few genes routinely incompatible with E. coli. In conclusion, rebuilding and booting a genome remains a feasible and pragmatic approach to creating a synthetic microbial cell. BioEssays 29:580–590, 2007. © 2007 Wiley Periodicals, Inc. (shrink)

Abstract:Calvin Warren talks about Heidegger's influence on Afropessimism, and about the philosophical significance of the Harlem Renaissance.

The title of Stewart’s biography is a tribute to Alain Locke’s seminal work, The New Negro: An Interpretation. This 1925 anthology highlighted the works of several up-and-coming black writers of the 20th century, planting these authors and, thus, a new black intellectual movement squarely in the public eye. While Alain Locke and John Dewey did not work directly together, Dewey’s philosophical approaches, specifically aesthetic valuation, significantly influenced Locke’s life. John C. Stewart provides a dense and thorough illustration of Locke’s use (...) of aesthetic valuation in his personal, professional, and educational experiences. Locke was pursuing his doctoral degree at Harvard University in Dewey’s discipline at... (shrink)

In the contemporary debate on moral status, it is not uncommon to find philosophers who embrace the the Principle of Full Moral Status, according to which the degree to which an entity E possesses moral status is proportional to the degree to which E possesses morally relevant properties until a threshold degree of morally relevant properties possession is reached, whereupon the degree to which E possesses morally relevant properties may continue to increase, but the degree to which E possesses moral (...) status remains the same. One philosopher who has contributed significantly to the contemporary debate on moral status and embraces the Principle of Full Moral Status is Mary Anne Warren. Warren holds not only that it is possible for some entities to possess full moral status, but that some entities actually do, e.g., normal adult human beings. I argue that two of Warren’s primary arguments for the Principle of Full Moral Status—the Argument from Pragmatism and the Argument from Explanatory Power—are significantly flawed. (shrink)

This chapter contains sections titled: The Validity of Anselm's Ontological Argument The Truth of the Anselmian Premises On Whether Anselm's Ontological Argument Begs the Question On Parodies The Validity of the Ontological Argument of Descartes and Leibniz On the Truth of the Descartes–Leibniz Premises Critiques of the Descartes–Leibniz Ontological Argument Ontological Arguments of the Twentieth Century Gödel's Ontological Argument On Whether Gödel's Argument is Sound The Modal Perfection Argument The Temporal‐Contingency Argument Conclusion References Appendix 1. Logic Matters Appendix 2. Formal (...) Proofs of Some Modal Arguments. (shrink)

'Justice' and 'democracy' have alternated as dominant themes in political philosophy over the last fifty years. Since its revival in the middle of the twentieth century, political philosophy has focused on first one and then the other of these two themes. Rarely, however, has it succeeded in holding them in joint focus. This volume brings together leading authors who consider the relationship between democracy and justice in a set of specially written chapters. The intrinsic justness of democracy is challenged, the (...) relationship between justice, democracy and impartiality queried and the relationship between justice, democracy and the common good examined. Further chapters explore the problem of social exclusion and issues surrounding sub-national groups in the context of democracy and justice. Authors include Keith Dowding, Richard Arneson, Norman Schofield, Albert Weale, Robert E. Goodin, Jon Elster, David Miller, Phillip Pettit, Julian LeGrand and Russell Hardin. (shrink)

This new edition of _A Companion to Contemporary Political Philosophy_ has been extended significantly to include 55 chapters across two volumes written by some of today's most distinguished scholars. New contributors include some of today’s most distinguished scholars, among them Thomas Pogge, Charles Beitz, and Michael Doyle Provides in-depth coverage of contemporary philosophical debate in all major related disciplines, such as economics, history, law, political science, international relations and sociology Presents analysis of key political ideologies, including new chapters on Cosmopolitanism (...) and Fundamentalism Includes detailed discussions of major concepts in political philosophy, including virtue, power, human rights, and just war. (shrink)

Utilitarianism, the great reforming philosophy of the nineteenth century, has today acquired the reputation for being a crassly calculating, impersonal philosophy unfit to serve as a guide to moral conduct. Yet what may disqualify utilitarianism as a personal philosophy makes it an eminently suitable guide for public officials in the pursuit of their professional responsibilities. Robert E. Goodin, a philosopher with many books on political theory, public policy and applied ethics to his credit, defends utilitarianism against its critics and (...) shows how it can be applied most effectively over a wide range of public policies. In discussions of such issues as paternalism, social welfare policy, international ethics, nuclear armaments, and international responses to the environment crisis, he demonstrates what a flexible tool his brand of utilitarianism can be in confronting the dilemmas of public policy in the real world. (shrink)

The respondent agrees with William Grassie that many windows on nature are possible; that emphasis must remain on the generation of order; that “chance” would better be recast as “contingency”; and that the ecological metaphysic has wide implications for a “politics of nature”. He accepts the challenge by Pedro Sotolongo to extend his metaphysic into the realm of pan-semiotics and agrees that an ecological perspective offers the best hope for solving the world’s inequities. He replies to Stanley Salthe that he (...) now agrees that the second law of thermodynamics is the overarching law of nature, but only when the duality inherent in of the concept of entropy is widely recognized. The respondent is enthusiastic over Jeffrey Lockwood’s extrapolation of process ecology to include the concept of “species” and over John Haught’s description of how the construct paves the way for a “theology of evolution” by recasting evolution as an unfolding “drama”. (shrink)

"Among the foremost Catholic philosophers of his generation. He has utilized the fullness of the Catholic intellectual tradition to brilliantly take the measure of modern philosophical thought... This volume is an expression of Robert Wood's singular philosophical outlook." -Jude Dougherty, dean emeritus, school of philosophy, The Catholic University of America.

In this strikingly original book, one of the leading scholars in the field focuses on the influential idea of deliberative democracy. Goodin examines the great challenge of how to implement the deliberative ideal among millions of people at once and comes up with a novel solution: 'democratic deliberation within'.

An example is given of a complete theory with minimal models of arbitrarily large minimality rank.

Being Human is the fruit of many years teaching Philosophical Anthropology, conducting Phenomenological Workshops, and reading classic texts in the light of a reflective awareness of the field of experience. Being Human is intended to look to what is typically assumed but not examined in much of current philosophical literature.